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| ntentional weight loss btmay result from loss o ewdb body fats, loss of body flu ids, muscle atrophy, or even a combination of theset is general 8ewdb ly regarded as a m edical problem when db a least 10% of a person's body weight has been lost in six mon t or 5% in the last montAnother criterion used for assessing weight that is too low i s the body mass iever, even lesser amounts of weight bt loss can be a cause for serious concern in a frail elderly person Unintentional k8ewdb weight loss can occur because of dban inadequately nutritious diet relativ e to a person's energ wdb y needs (generally called malnutrition). Disease processes, change s in metabolism, hormonal changes, medications or other treat wdb ments, disease- or treatme nt-related dietary changes, or wdb reduced ap dbpet 8ewdb ite associated with a disease or treatment c an also cau k8ewdb se unintentional weight losPoo ewdb r nutrient utilization can lead to weight loss, and can be caused by fistulae i k8ewdb n the gastrointestinal tract, diarrh 8ewdb ea, drug-nutrient int eraction, enzyme depletion and muscle atrophy. Continuing weight loss may dete ewdb riorate into wasting, a vaguely defined condition called c achexia.[6] Cach dbexia differs db from starvation in part b 8ewdb ecause it involves a systemic infla mmatory response.It is associated with poorer ewdb outcomesIn the advanced stages of progressive disease, metabolism can change so that they lose wdb weight even when they are gettin g what is normally regarded as adequate nutrition dband the body cannot compensate. This leads to a condition call ewdb ed anorexia wdb cachexia syndromnd a 8ewdb dditional nutrition or supplement ation is unlikely to help small amounts, nausea, anemia, weakness and fati Serious weight loss may reduce quality k8ewdb of life, impair treatment effectiv |

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